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Though the levels of phenylalanine in serum showed no significant differences between pCR and non-pCR, the two products of phenylalanine metabolism, 3-PPA and PAGln, which has been proved associated with gut microbiome 33,55 , showed significant differences between pCR and non-pCR patients, suggesting that the gut bacteria involved the different responses of nCRT therapy

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Lyophilization (freeze-drying) removes moisture while preserving peptide integrity - ensuring stability during shipping and long-term storage