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Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACs | Communications Chemistry

3.3.2 Ivermectin: oral and topical uses The US FDA have approved 1% ivermectin cream for the treatment of PPR (155)

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A 12-week clinical trial [55] with children ( n = 31) with autism administered 60 mg/kg/day in three doses (maximum dose of 4200 mg/day) found that although there was no significant impact on the social impairment associated with autism, there was a significant impact on boosting the glutathione levels in the children