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Vías de señalización documentadas en literatura: Estimulación folicular: modelos ex vivo de folículo piloso humano documentan elongación y proliferación de células de la papila dérmica Señalización por cobre: el complejo de cobre (II) se asocia en literatura a modulación de matriz extracelular y angiogénesis dérmica 🔬 EVIDENCIA CIENTÍFICA DOCUMENTADA Pyo HK et al., Biol Pharm Bull 2007 (PMID 17703734): AHK-Cu en estudios de crecimiento de folículo piloso humano ex vivo y proliferación de células de papila dérmica Pickart L, Margolina A, Int J Mol Sci 2018 (PMID 30041448): revisión de péptidos de cobre en remodelación dérmica y matriz extracelular Material de investigación únicamente
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Reduced GPX4 expression in turn means that this protective system is reduced and thus enhancing susceptibility of chondrocytes to oxidative stress via MAPK/NF-κB signaling (Liu et al., 2024)
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