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while GLUT4 has a high affinity for glucose, it is responsive to insulin ( GLUT1 in high glucose culture conditions, whereas chondrocytes affected by OA do not suppress GLUT1 ( IL-1β , which can affect mitochondrial activity and glucose uptake ( IL-1β and TNF-α , along with the progression of OA disease, enhance cholesterol uptake by chondrocytes and facilitate the production of oxysterol metabolites
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