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55 Moreover, another study in 2023 showed that ALDH1A3 expression downregulated in TMZ-resistant LN229 GBM cell lines, which correlated with their resistance to ferroptosis despite the RSL3’s induction of lipid peroxidation
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This is in agreement with reports describing a collapse in the antioxidant defense system at high salt concentrations, characterized by the depletion of GSH and AsA pools and accumulation of the oxidized forms (GSSG and DHA) ( When considering other plant species, varying degrees of salt tolerance result in distinct redox responses ( Cakile maritima ( Cakile maritima ( A
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