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These constraints can be mitigated by anchoring point-of-care readouts to validated lab assays, implementing specificity controls (e.g., SOD/catalase for O 2 Β·β/H 2 O 2 , chelators for Fenton dependence), and using compartment-targeted, ratiometric reporters with documented calibration (KrΓ³l and BrzeΕΊnicki 2023
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