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most common site of melanotic macule Smoker's Melanosis πΉ Benign oral mucosal pigmentation seen in smokers πΉ Due to increased melanin production, not β melanocyte number Clinical πΉ Diffuse brown macules/patches πΉ Usually flat, irregular πΉ aloe-vera-drink
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Additionally, risk factors such as obesity, T2DM, chronic inflammation, and gut microbiota dysbiosis exacerbate oxidative stress, further promoting disease progression (Figure 1) [3,17,63]
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