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Finally, GCLM expression also changes in a biphasic manner during BDL and when hepatocytes are treated with lithocholic acid [90,136 - see below under cholestatic liver injury]
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Mechanistically, CTIF associates with both the eukaryotic translation elongation factor 1 alpha 1 (eEF1A1) and dynactin 1 (DCTN1) through its N-terminal region, forming a functional complex called CTIF-eEF1A1-DCTN1 (CED) complex
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