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Osteoarthritis exploration is limited to preclinical animal work — Kwon & Park (Ann Clin Lab Sci 2015, PMID 26275694) reported intra-articular AOD-9604 plus hyaluronic acid was superior to either alone in a collagenase-induced rabbit OA model
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The associated S plot (Fig 2A′) indicated the NMR chemical shifts, then assigned to metabolites, that discriminated between the two classes (Figs 2C and S3)
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