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The dogs were divided into 3 groups depending on the received dose, including the following 3 doses: 0 mg/day 236 mg/d 492 mg/d Each group was further divided into two subgroups, receiving either 110% or 120% of their Maintenance Energy Requirement (MER), which was evaluated in a metabolic chamber at baseline

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This design simultaneously overcomes curcumin’s three major absorption barriers—chemical instability, poor solubility, and limited permeability